P . AERUGINOSA TYPE III AND TYPE VI SECRETION SYSTEMS MODULATE EARLY RESPONSE GENE EXPRESSION IN TYPE II PNEUMOCYTES IN VITRO

P . aeruginosa type III and type VI secretion systems modulate early response gene expression in type II pneumocytes in vitro

Abstract Background Lung airway epithelial cells are part of innate immunity and the frontline of defense against bacterial infections.During infection, airway epithelial cells secrete proinflammatory mediators that participate in the recruitment of immune cells.Virulence factors expressed by bacterial pathogens can alter epithelial cell gene expre

read more

CTCF and CohesinSA-1 Mark Active Promoters and Boundaries of Repressive Chromatin Domains in Primary Human Erythroid Cells.

BackgroundCTCF and cohesinSA-1 are regulatory proteins involved in a number of critical cellular processes including transcription, maintenance of chromatin domain architecture, and insulator function.To assess changes in the CTCF and cohesinSA-1 interactomes during erythropoiesis, chromatin immunoprecipitation coupled with high throughput sequenci

read more